Welcome to the Emmott Lab!
What we do:
The Emmott Lab uses proteomics to study viruses and how they replicate. In particular, RNA viruses important for human and animal health such as Norovirus, Polio, Chikungunya virus, MERS coronavirus, and viruses which serve as useful models to study these pathogens such as Semliki Forest virus & Avian coronavirus. The lab does what is known as ‘basic science’: early-stage investigations which lay the groundwork for more applied or clinical studies. By learning the fundamentals of how these viruses replicate and interact with the cells they infect, we can learn how to treat infections, design better vaccines or antiviral drugs, or even convert viruses from pathogens into useful gene therapy or anticancer tools.
The lab makes extensive use of mass spectrometry-based proteomics in its work, including single-cell proteomics (SCoPE2). These methods are used alongside virology, molecular biology, microscopy, and integrative ‘omics approaches to answer questions on how RNA viruses replicate and interact with the host cell.
Research in the lab falls under several main themes:
|RNA virus replication||Viral proteases and their targets||Viral interactions with ribosomes|
In addition, we are interested in the development of proteomic methods which allow us to better understand these systems.
Where to find us:
Centre for Proteome Research, University of Liverpool
|The Emmott Lab is part of the Centre for Proteome Research (CPR) at the University of Liverpool alongside the Eyers and Beynon labs, which all make heavy use of mass spectrometry to answer biological questions. The CPR’s remit is the ‘advancement of technological capabilities for proteomics analysis across the biological and biomedical sciences’. All three groups are also part of the Department of Biochemistry, within the Institute of Integrative Biology.
Alongside research, the CPR has a role as a Shared Research Facility (SRF), part of the University of Liverpool’s Technology Directorate. The SRF provides a proteomics service and collaborative access to users wishing to apply mass spectrometry to their own research. For more details on the SRF please see here.
|The city of Liverpool is in the North-West of England, with a population of 490,000 and 2.2 million living in the wider Liverpool metropolitan area. The city was named European Capital of Culture in 2008 and contains the most art galleries and museums of any city in the UK outside London. It is most famous for music (The Beatles) and football (Liverpool F.C.).
Unlike London, Liverpool benefits from very affordable cost of living. It also has good transport links by rail and car to nearby Manchester, as well as Birmingham and London. The local Liverpool John Lennon Airport also offers domestic and international flights.
Research in the Emmott lab is currently supported by funding from the University of Liverpool, and Wellcome Trust