Welcome to the Emmott Lab!
What we do:
The Emmott Lab uses proteomics to study viruses and how they replicate. In particular, RNA viruses important for human and animal health such as Norovirus and SARS-CoV-2. The lab does what is known as ‘basic science’: early-stage investigations which lay the groundwork for more applied or clinical studies. By learning the fundamentals of how these viruses replicate and interact with the cells they infect, we can learn how to treat infections, design better vaccines or antiviral drugs, or even convert viruses from pathogens into useful gene therapy or anticancer tools.
The lab makes extensive use of and develops mass spectrometry-based proteomic methods in its work, including single-cell proteomics (SCoPE2). These methods are used alongside virology, molecular biology, microscopy, and integrative ‘omics approaches to answer questions on how RNA viruses replicate and interact with the host cell.
Research in the lab falls under several main themes:
|RNA virus replication||Viral proteases and their targets||Viral interactions with ribosomes|
In addition, we are interested in the development of novel proteomic methods such as single-cell proteomics which allow us to better understand these systems.
Where to find us:
Centre for Proteome Research, University of Liverpool
|The Emmott Lab is part of the Centre for Proteome Research (CPR) at the University of Liverpool alongside the Eyers and Beynon labs, which all make heavy use of mass spectrometry to answer biological questions. The CPR’s remit is the ‘advancement of technological capabilities for proteomics analysis across the biological and biomedical sciences’. All three groups are also part of the Department of Biochemistry & Systems Biology, within the Institute of Systems, Molecular & Integrative Biology.
Alongside research, the CPR has a role as one of the University of Liverpool’s Shared Research Facilities (SRF). The SRF provides a proteomics service and collaborative access to users wishing to apply mass spectrometry to their own research. For more details on the SRF please see here.
|The city of Liverpool is in the North-West of England, with a population of 490,000 and 2.2 million living in the wider Liverpool metropolitan area. A historic port city, Liverpool city was named European Capital of Culture in 2008 and contains the most art galleries and museums of any city in the UK outside London. It is most famous for music (The Beatles), football (Liverpool F.C. & Everton), and its architecture.
Unlike London, Liverpool benefits from very affordable cost of living. It also has good transport links by rail and car to nearby Manchester, as well as Birmingham and London. The local Liverpool John Lennon Airport also offers domestic and international flights.
The Emmott lab is grateful to its funders for supporting the labs work. Research in the Emmott lab is currently supported by funding from the MRC, Academy of Medical Sciences, BBSRC, the Houghton Trust and UK-ICN (UK-International Coronavirus Network). Previously the lab has received support from the Royal Society and University of Liverpool Wellcome ISSF funds.