A funded PhD studentship is available working primarily in the Centre for Proteome Research with Ed, with support from Dr Lance Turtle at Liverpool. This project will build upon the Emmott labs recent data in Meyer et al. 2020 which identified previously unknown proteolytic cleavage sites in important SARS-CoV-2 proteins, as well as cellular proteins which could be targeted with existing drugs to reduce SARS-CoV-2 replication.
You will extend and combine this data with cutting-edge single-cell proteomic approaches to study how cleavage events vary between infected cells, and the impact this variation has on the outcome of coronavirus infection at single-cell level, and in vitro and cell-based assays to characterize and validate cleavage.
This project covers both ‘wet-lab’ and computational training. You will receive training in state of the art mass spectrometry approaches including N-terminomics, single-cell proteomics (SCoPE2), in vitro and cell-based assays, data analysis in Matlab or R, including merging datasets, and standard cell culture and virological methods for handling SARS-CoV-2.
Funding is available for UK students. More details on this project can be found here. The deadline for applications is May 31st 2021.