A new preprint in collaboration with the Sweeney lab is now out: Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells. In this work we show that murine norovirus mRNA with the viral VPg protein attached to its 5′ is resistant to the translation inhibition effects of Ifit1 and is not bound, whereas in vitro transcribed norovirus mRNA bearing a 5′ Cap is inhibited. However we showed Ifit1 knockout lines show enhanced norovirus replication, and observe these lines show diminished interferon signaling upon stimulation of cytoplasmic RNA sensing. The preprint is available here.

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