We just published a new preprint in bioRxiv. We study how norovirus polyprotein precursors containing the norovirus protease (NS6) confer protein:protein interactions and localisation upon the protease. This regulates the ability of the protease to access specific substrates. As the rates of polyprotein cleavage result in shifts in precursor abundance throughout infection, this allows the virus to temporally and spatially control protease activity.


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